本文报道用化学药物配合10％异烟肼溶液快速静脉注射治疗120例初次发现与慢性破坏性肺结核的结果。 120例中女31、男89例。年龄17～69(平均34.4±0.5)岁。诊断原发结核综合征1例,播散性结核2例,局灶性9例,浸润性89例,纤维空洞性19例。所有患者都确定为溶解期,痰或气管洗涤液发现结核杆菌93例(77.5％),其中6例(6.5％)有耐药性。放射学改变:肺右侧40例,左侧24例,两侧56例;病变局限在1～3个肺段58例,4～16个肺段62例;有1个空洞者71例,余49例有2个或多个空洞。静脉注射除星期日外,每日进行,异烟肼的昼夜剂量为15mg/kg体重,总量不超过1g(10％异烟肼溶 This article reports the results of 120 cases of primary findings and chronic destructive pulmonary tuberculosis treated with chemical drugs and 10% isoniazid solution intravenously. Among 120 cases, 31 were female and 89 were male. Age 17 to 69 (average 34.4±0.5) years old. Diagnosis of primary tuberculosis syndrome in 1 case, disseminated tuberculosis in 2 cases, 9 cases of focal, invasive 89 cases, 19 cases of fiber cavitation. All patients were confirmed to be in the dissolution phase. Ninety-three cases (77.5%) of Mycobacterium tuberculosis were found in sputum or tracheal washes, of which 6 cases (6.5%) had drug resistance. Radiological changes: 40 cases of right lung, 24 cases of left, 56 cases on both sides; lesions confined to 58 cases in 1 to 3 lung segments, 62 cases in 4 to 16 lung segments, and 71 cases in 1 cavity. 49 cases had 2 or more holes. Intravenous injections were performed daily except Sundays. The daily dose of isoniazid was 15 mg/kg body weight and the total amount did not exceed 1 g (10% isoniazid solution).