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目的观察根据药敏试验选择敏感抗真菌药口服联合氯喹那多-普罗雌烯阴道片治疗复发性外阴阴道假丝酵母菌病(RVVC)的疗效。方法将59例RVVC患者随机分为两组,采用强化和巩固治疗,观察组30例口服敏感药物,阴道放置氯喹那多-普罗雌烯阴道片,对照组29例口服氟康唑,阴道放置氯喹那多-普罗雌烯阴道片,治疗3个月。治疗后1个月、3个月复查。结果治疗后1个月观察总有效率,观察组100%,对照组69.0%(P<0.01),治疗后3个月观察复发率,观察组3.7%,对照组42.1%(P<0.01)。结论治疗RVVC应进行真菌培养及药敏试验,选择敏感药物口服联合氯喹那多-普罗雌烯阴道片治疗调整菌群,改善阴道微环境可提高治愈率,减少复发。
Objective To observe the curative effect of oral administration of sensitive antifungal agents combined with chloroquineto-proestradiol vaginal tablets in the treatment of recurrent vulvovaginal candidiasis (RVVC) according to the susceptibility test. Methods Fifty-nine patients with RVVC were randomly divided into two groups. Forty cases were treated with intensive and consolidate treatment. 30 cases of oral sensitive drugs were observed in the observation group. Chloroquinanadino-vaginal vaginal tablets were placed in the vagina. In the control group, 29 cases were given fluconazole, That much - Pro female ethin vaginal tablets, treatment for 3 months. 1 month after treatment, 3 months review. Results The total effective rate was observed one month after treatment. The observation group was 100% and the control group was 69.0% (P <0.01). The recurrence rate was observed at 3 months after treatment. The observation group was 3.7% and the control group 42.1% (P <0.01). Conclusions The treatment of RVVC should be carried out in fungal culture and drug susceptibility testing. Choosing sensitive drugs orally combined with chloroquineto-proestradiol vaginal tablets in the treatment of adjusting flora, and improving the vaginal microenvironment can improve the cure rate and reduce recurrence.