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给家兔侧脑室注射选择性α_1肾上腺素受体激动剂苯肾上腺素(2μg/kg),可引起较持久的血压升高,用哌唑嗪(2μg/kg)侧脑室注射预先处理动物,可取消其升压作用。哌唑嗪预先处理还可取消去甲肾上腺素(2μg/kg)脑室注射引起的轻度血压升高,而呈降压作用。可乐宁(2μg/kg)侧脑室注射引起明显的血压下降,这种作用不能被哌唑嗪对抗(且哌唑嗪呈协同性降压作用),但可被妥拉苏林(90μg/kg侧脑室注射)对抗。结果进一步证明:家兔中枢可能存在α_1和α_2肾上腺素受体亚型,α_1受体被激活时血压升高,α_2受体被激动时可使血压降低;哌唑嗪的降压作用可能亦有中枢α_1受体阻滞作用的参与。
Addition of phenylephrine (2 μg / kg), a selective alpha 1 adrenergic receptor agonist, to the lateral ventricle of rabbits resulted in more sustained increases in blood pressure, preconditioning of animals with prazosin (2 μg / kg) intracerebroventricular injection Cancel its boost effect. Prazosin pretreatment can also be canceled norepinephrine (2μg / kg) intraventricular injection caused mild blood pressure, but was antihypertensive effect. Intracerebroventricular (icv) injection of clonidine (2 μg / kg) caused a significant drop in blood pressure that could not be countered by prazosin (and systolic blood pressure was reduced by prazosin) but was tolerated by tolazulin (90 μg / kg side Intraventricular injection) confrontation. The results further prove that there may be α_1 and α_2 adrenergic receptor subtypes in rabbit central nervous system. When α_1 receptor is activated, blood pressure may be increased and α_2 receptor may be activated to decrease blood pressure. Prazosin may also have antihypertensive effects Central alpha 1 receptor blockade participation.