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白血病细胞与骨髓基质细胞(BMSCs)在白血病微环境中相互作用,BMSCs可促进白血病细胞的生长和增殖、抑制凋亡,白血病细胞可通过干扰BMSCs而改变骨髓微环境~[1],从而改变BMSCs的生物学特性。现将其相互影响的研究进展综述如下。1 BMSCs的定义与白血病微环境的生物学特性BMSCs来源于胚胎发育的间充质干细胞(MSCs)~[2],是骨髓微环境中的重要组成部分,由成纤维
Leukemic cells and bone marrow stromal cells (BMSCs) interact in the leukemic microenvironment. BMSCs can promote the growth and proliferation of leukemic cells and inhibit the apoptosis. Leukemic cells can change the bone marrow microenvironment by interfering with BMSCs [1] Biological characteristics. Now the interaction of their research progress are summarized below. 1 Definition of BMSCs and Biological Characteristics of Leukemic Microenvironment BMSCs are derived from embryonic mesenchymal stem cells (MSCs) ~ [2] and are an important part of bone marrow microenvironment. They are composed of fibroblasts