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在针剂生产中,为了保证质量,常在安瓿中灌充惰性气体,例如抗坏血酸注射液、盐酸硫胺注射液等。由于氮气不易购得,而且氮气较二氧化碳气为轻,易于逸散,所以生产中常用二氧化碳气代替。灌充的目的是驱除安瓿中的空气。实际上在操作过程中不可能完全驱除,必然有一小部份空气剩留在安瓿内。这剩留空气量决定了针剂的质量,如果剩留空气量太高,必然妨害针剂质量。
In the production of injection, in order to ensure the quality, often filled in ampoules inert gas, such as ascorbic acid injection, thiamine hydrochloride injection. Because nitrogen is not easy to buy, and nitrogen is lighter than carbon dioxide gas, easy to escape, so commonly used in production of carbon dioxide instead. The purpose of filling is to get rid of the air in the ampoule. In fact, it is impossible to get rid of the operation completely, so a small part of the air must remain in the ampoule. The amount of residual air determines the quality of the injection, if the amount of residual air is too high, it will inevitably hinder the quality of the injection.