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目的 研究四抗感冒口服液 (CCD)的抗病毒、抗菌及镇痛作用。方法 应用病毒致细胞病变作用观察CCD的抗病毒作用 ;应用平皿挖洞灌药法观察CCD的抑菌作用 ;应用热诱发小鼠疼痛反应模型和冰醋酸诱导小鼠扭体反应模型观察CCD对疼痛的抑制作用。结果 CCD对疱疹病毒Ⅰ型的半数有效浓度为 0 98g·L-1。CCD 1 0 0g·ml-1对金葡菌(ATCC 2 5 92 3)、金葡菌 (MRSA)、表皮葡萄球菌、肺炎链球菌和草绿色链球菌均有抑制作用。CCD 5 0g·kg-1和 10 0g·kg-1可明显延长小鼠热痛反应潜伏期 (P <0 0 5 ,P <0 0 1) ,提高小鼠的痛阈值 ,且维持时间较阿司匹林长。CCD 10 0g·kg-1与 2 0 0g·kg-1对小鼠扭体反应次数有明显抑制作用 (P<0 0 1)。结论 CCD具有一定的体外抗病毒、抗菌作用 ;CCD具有镇痛作用 ,且作用维持时间较长。
Objective To study the antiviral, antibacterial, and analgesic effects of quaternary anti-cold oral liquid (CCD). Methods The antiviral effect of CCD was observed by virus-induced cytopathogenic effect; the bacteriostatic effect of CCD was observed by plate-dip burrowing; and the pain-response model of mice induced by heat and the writhing response model induced by glacial acetic acid were used to observe CCD pain. The inhibitory effect. Results The effective half concentration of CCD for herpesvirus I was 0 98g·L-1. CCD 1 0 0g·ml -1 inhibited Staphylococcus aureus (ATCC 2 5 92 3), Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Streptococcus pneumoniae and Streptococcus viridans. CCD 5 0g·kg-1 and 100 g·kg-1 significantly prolonged the incubation period of thermal pain in mice (P < 0.05, P <0.01), increased the pain threshold of mice, and maintained longer than that of aspirin. . CCD 10 0g·kg-1 and 200 g·kg-1 significantly inhibited the number of writhing responses in mice (P < 0 01). Conclusion CCD has certain antiviral and antibacterial effects in vitro; CCD has analgesic effect and has a longer duration of action.