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目的:进一步了解血小板活化因子(PAF)与狼疮性肾炎(LN)病理类型的关系。方法:对35例不同病理类型的LN患者与31例正常对照患者的血浆和尿液PAF水平进行比较。结果:LN患者血浆及尿液PAF水平均比对照组显著增高(P<0.05),且随病理损伤程度的加重其水平亦增高;血浆和尿液PAF水平与病变程度之间均存在密切相关(P<0.01);血浆PAF水平与尿液PAF水平之间亦存在密切相关(P<0.01)。结论:PAF水平可作为判断LN免疫病理损伤程度的重要指标。
Objective: To further understand the relationship between platelet activating factor (PAF) and pathological type of lupus nephritis (LN). Methods: Plasma and urine PAF levels were compared between 35 LN patients with different pathological types and 31 normal controls. Results: PAF levels in both plasma and urine of patients with LN were significantly higher than those of the control group (P <0.05), and the level of PAF was also increased with the degree of pathological injury. There was a close correlation between PAF level in plasma and urine and the degree of pathological changes P <0.01). There was also a close correlation between plasma PAF level and urine PAF level (P <0.01). Conclusion: PAF level can be used as an important index to judge the degree of immune pathological damage of LN.