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裸鼠是遗传性免疫缺陷动物的一种，分为裸大鼠（ｎｕｄｅｒａｔｓ）和裸小鼠（ｎｕｄｅｍｉｃｅ）。异种移植的肿瘤在裸小鼠体内的生长受肿瘤自身的相关特性及裸小鼠体内的因素影响。裸小鼠移植瘤基本保留着原发肿瘤的生物学特性，但也在一定程度上表现出一定的异质性。裸小鼠视网膜母细胞瘤及葡萄膜黑色素瘤移植瘤的建立，为研究这些肿瘤的发病机制以及观察和评估各种治疗方法的效果等方面提供了一个良好的体内动物模型。
Nude mice are a group of genetically immunodeficient animals divided into nuderats and nudemice. The growth of xenografted tumors in nude mice is influenced by the tumor’s own characteristics and factors in nude mice. Nude mouse xenograft basically retains the biological characteristics of the primary tumor, but also to some extent, showed some heterogeneity. The establishment of nude mouse retinoblastoma and uveal melanoma xenografts provides a good in vivo animal model for studying the pathogenesis of these tumors and for observing and evaluating the effects of various treatments.