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目的探讨脂联素、瘦素及其比值与2型糖尿病胰岛素抵抗的相关性。方法检测250例2型糖尿病人群血清脂联素(APN)、瘦素(LPN)、高密度脂蛋白(HDL)、甘油三酯(TG)及体质指数(BM I)等指标,并同时按不同空腹血糖水平分为三组:A组(<7.8 mmol/L)、B组(≥7.8 mmol/L,<9.4 mmol/L)、C组(≥9.4 mmol/L),分析不同组间脂联素、瘦素及其比值(A/L-ratio)和HOMA-R与各指标间的相关性。结果脂联素水平与TG呈负相关,与HDL呈正相关;瘦素则与BM I及TG存在显著负相关,与HDL无明显相关关系存在;而脂联素与瘦素的比值分别与BM I和TG呈负相关,与HDL呈正相关,同时在不同空腹血糖水平的分组中,血清脂联素、瘦素及其比值和HOMA-R与胰岛素抵抗各指标(BM I、HDL、TG)间也存在着不同的相关关系。结论脂联素与瘦素的比值相对于脂联素、瘦素、HOMA-R单独而言,是一个比较好的评估胰岛素抵抗的指标。
Objective To investigate the correlation between adiponectin, leptin and its ratio and insulin resistance in type 2 diabetes. Methods The levels of serum adiponectin (APN), leptin (LPN), high density lipoprotein (HDL), triglyceride (TG) and body mass index (BMI) were measured in 250 type 2 diabetic patients. Fasting plasma glucose was divided into three groups: group A (<7.8 mmol / L), group B (≥7.8 mmol / L, <9.4 mmol / L) and group C (≥9.4 mmol / L) The correlation between A / L-ratio, HOMA-R and each index was analyzed. Results The level of adiponectin was negatively correlated with TG and positively correlated with HDL. Leptin was negatively correlated with BM I and TG, but not with HDL. However, the ratio of adiponectin to leptin was correlated with BM I Negatively correlated with TG and positively correlated with HDL. In different fasting blood glucose groups, serum adiponectin, leptin and their ratios as well as between HOMA-R and insulin resistance index (BM I, HDL, TG) There are different correlations. Conclusion The ratio of adiponectin to leptin is a good indicator of insulin resistance relative to adiponectin, leptin and HOMA-R alone.