目的探讨米索前列醇不同给药途径预防产后出血的临床疗效。方法选取240例产妇,随机分成甲、乙、丙3组,各80例。甲组产妇采用直肠给药,乙组产妇采用阴道给药,丙组产妇采用口服给药,并比较预防产后出血疗效。结果 3组产妇不同给药途径的产后出血量及第3产程时间相比,差异无统计学意义(P>0.05);甲组不良反应发生率明显高于其他两组,差异有统计学意义(P<0.05)。结论米索前列醇在减少产后出血和缩短第3产程有一定的效果,但不同给药途径与预防产后出血的临床效果关系不大。 Objective To investigate the clinical efficacy of different routes of misoprostol in preventing postpartum hemorrhage. Methods 240 maternal women were randomly divided into three groups: A, B and C, 80 cases each. Group A maternal rectal administration, Group B maternal vaginal administration, Group C maternal oral administration, and more to prevent postpartum hemorrhage. Results There were no significant differences in the amount of postpartum hemorrhage and the third stage of labor among the three groups (P> 0.05). The incidence of adverse reactions in group A was significantly higher than the other two groups (P <0.05) P <0.05). Conclusion Misoprostol has some effect in reducing postpartum hemorrhage and shortening the third stage of labor, but the different routes of administration have little relation with the clinical effect of preventing postpartum hemorrhage.