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目的 观察在青光眼滤过性手术中使用丝裂霉素C的时间,适宜浓度及并发症。方法 对19例(31只眼)青光眼患者施板层巩膜下巩膜咬切术。使用0.5mg/ml丝裂霉素C浸3min,冲净。结果 术后平均随访18个月,形成功能性滤过泡者占93％,非功能性滤过泡者占7％。不用任何药物,眼压维持≤20mm Hg者占93％,≥21mmHs者占7％。结论 丝裂霉素C作为青光眼滤过性手术的辅助药物,可有效地抑制术区成纤维细胞增殖,减少术区瘢痕形成,延长滤过功能,降低眼内压,提高手术成功率。但不同个体反应不一致,使用时要注意适应证的选择。
Objective To observe the time, appropriate concentration and complications of mitomycin C in filtering glaucoma surgery. Methods Thirteen patients (31 eyes) with glaucoma underwent scleral sclerectomy. Use 0.5mg / ml mitomycin C dip 3min, rinse. Results The average postoperative follow-up was 18 months, accounting for 93% of patients with functional filtering bleb and 7% of non-functioning filtering bleb. Without any medication, intraocular pressure maintained 93% of those with ≤20 mm Hg and 7% ≥21 mmHs. Conclusion Mitomycin C, as an auxiliary drug for glaucoma filtration surgery, can effectively inhibit fibroblast proliferation in operation area, reduce scar formation in operation area, prolong filtration function, decrease intraocular pressure and improve operation success rate. However, the reaction of different individuals is inconsistent, use should pay attention to the choice of indications.