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过去人们曾强调巨噬细胞在宿主体内有抗癌作用,事实证明它确对肿瘤的生长有监护机制。动物实验发现在瘤细胞接种之前先刺激巨噬细胞系统能增强宿主的抗瘤能力,如降低巨噬细胞的功能,则宿主对瘤易感。Halpern 等(1963)曾观察小鼠感染卡介苗后,可增强抗肉瘤 J 的能力,这与巨噬细胞系统活性的增强有关,卡介苗刺激巨噬细胞系统,使其在宿主体内发挥抗癌作用。同样,Walmark 等(1974)发现短小棒状杆菌的抑瘤生长也需有活性巨
In the past people have stressed that macrophages in the host anti-cancer effect, it turns out that it does have a monitoring mechanism of tumor growth. Animal experiments found that stimulating the macrophage system prior to tumor cell inoculation enhances the antitumor activity of the host, such as reducing macrophage function, the host is susceptible to the tumor. Halpern et al. (1963) observed that the ability of anti-sarcoma J after mice to have been infected with BCG is related to the enhancement of the activity of macrophage system. BCG stimulates the macrophage system to exert anticancer effect in the host. Similarly, Walmark et al. (1974) found that the growth inhibition of Corynebacterium parvum was also required to be viable