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迷走神经切断术术中及术后测定切断是否完全对估价术后症状或溃疡复发甚为必要。作者采用PCP-GABA进行动物实验,观察其在迷走神经干切断术(以下称TV)前后刺激胃酸分泌的作用以及是否有低血糖和心动过速等胰岛素的副作用;并探索术中用PCP-GABA刺激后胃粘膜pH的变化是否可用以判断TV的完全性。实验方法:取体重16～24kg的狗5只,分别做两次手术,先于胃体低位插入Thomas管制成慢性胃瘘模型,并作幽门成形术。第二次手术时经左八肋间进胸作TV,近横膈处切除2 cm,有副迷走神经或左右迷走神经交通支者也予以切断。TV前作PCP-GABA试验(静脉一次量0.5 mg/kg)、改良假饲试验(牛骨一块
Vagus nerve transection surgery and postoperative determination of whether the cut off completely evaluate the postoperative symptoms or ulcer recurrence is necessary. The author used PCP-GABA animal experiments to observe the role of gastric acid secretion before and after vagotomy (hereinafter referred to TV) and whether there is hypoglycemia and tachycardia and other side effects of insulin; and explore intraoperative use of PCP-GABA stimulation After gastric mucosal pH changes can be used to determine the TV’s completeness. Experimental Methods: Take 5 dogs with body weight of 16 ~ 24kg and perform operation twice respectively, insert the Thomas into chronic gastric fistula model at the lower part of gastric body, and make pyloroplasty. The second surgery by the left intercostal space into the chest for TV, near the diaphragm at resection of 2 cm, a sub vagus nerve or left vagus nerve traffic support also be cut off. TVP before the PCP-GABA test (intravenous 0.5 mg / kg), improved feeding test (a piece of bovine