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目的探讨莫西沙星和左氧氟沙星治疗老年耐多药肺结核(MDR-PTB)患者的临床疗效。方法选取2014年2月至2015年11月辽宁省鞍山市立山区双山医院收治的80例老年MDR-PTB患者作为研究对象,按随机数字表法将其分为观察组与对照组,各40例。两组患者均给予常规抗结核治疗,同时观察组患者采用莫西沙星进行治疗,对照组患者口服左氧氟沙星,比较两组患者治疗后痰菌转阴率、病灶吸收率及不良反应发生情况。结果治疗后,观察组患者的痰菌转阴率明显高于对照组,差异有统计学意义(P<0.05);观察组患者的病灶吸收率明显高于对照组,差异有统计学意义(P<0.05)。结论采用莫西沙星治疗MDR-PTB,能显著提高患者的痰菌转阴率和病灶吸收率,且不良反应较少。
Objective To investigate the clinical efficacy of moxifloxacin and levofloxacin in the treatment of elderly patients with multi-drug resistant pulmonary tuberculosis (MDR-PTB). Methods Eighty elderly patients with MDR-PTB treated in Shuangshan Hospital, Lianshan District, Anshan City, Liaoning Province from February 2014 to November 2015 were selected as study subjects and divided into observation group and control group according to random number table method example. Both groups were given conventional antituberculous therapy. At the same time, patients in the observation group were treated with moxifloxacin, while those in the control group were given oral levofloxacin. After treatment, sputum negative rate, absorption rate and adverse reactions were compared between the two groups. Results After treatment, the sputum negative rate in the observation group was significantly higher than that in the control group (P <0.05), and the absorption rate in the observation group was significantly higher than that in the control group (P <0.05). Conclusion Moxifloxacin treatment of MDR-PTB can significantly improve the patient’s sputum negative rate and the rate of absorption of the lesion, and fewer adverse reactions.