梯络龙系Mayer及Kruger首次发现的一种低分子口服干扰素诱生剂。具有抗病毒,抗肿瘤以及免疫调节等多种作用。前已报道,梯络龙对实验性矽肺大鼠具有明显的疗效,同时,可诱生干扰素作用。此后,我们又进行了一些梯络龙衍生物的药物筛选实验,其中发现梯—肟和梯—芴对大鼠实验性矽肺亦有明显的疗效。为了进一步观察其慢性毒性作用及其三致实验,因此,对上述三种药物进行急性毒性研究。 A long-acting, low-molecular-weight oral interferon inducer was first found in the venomous series Mayer and Kruger. With anti-virus, anti-tumor and immune regulation and other effects. It has been reported before that Tieluolong has obvious curative effect on experimental silicosis rats and at the same time can induce interferon effect. Since then, we have conducted some drug screening experiments with ladder-type derivatives, in which it was found that ladder-oxime and ladder-fluorene have significant therapeutic effects on experimental silicosis in rats. In order to further observe its chronic toxicity and its triple effect, acute toxicity studies of the above three drugs were conducted.