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经胃镜检查证实的十二指肠球部溃疡40例,每天临睡前服甲氰咪胍0.8,并与该药常规用法(0.23/d,0.41/晚)对照。治疗3～6周,溃疡愈合率前者为87.5%,后者为75%;疼痛消失时间前者平均9.5天,后者13天;晨间空腹胃酸的降低前者也优于后者。甲氰咪胍是一种治疗消化性溃疡的有效药物,常规的用法是,0.2,Tid,0.4临睡前一次(下称四次疗法),根据 Gledhill 等试验报告,自1985年1月～1986年5月,我们用南宁制药二厂生产的甲氰咪胍0.8每天临睡前服药一次的方法(下称一次疗法)治疗十二指肠球部溃疡40例,并与四次疗法治疗的40例对照,现将观察结果报告如下。
Forty cases of duodenal ulcer confirmed by gastroscopy were treated with Cimetidine 0.8 before going to bed every day, and compared with the routine use (0.23 / d, 0.41 / night) of the drug. The treatment of 3 to 6 weeks, the former was 87.5% ulcer healing rate, the latter was 75%; pain disappear time the former average 9.5 days, the latter 13 days; morning fasting acid lower than the former is better than the latter. Cimetidine is a potent drug for the treatment of peptic ulcer. Conventional usage is 0.2, Tid, 0.4 before going to sleep (hereinafter referred to as the four treatments), according to the Gledhill test report, from January 1985 to 1986 In May of this year, we used Cimetidine 0.8 produced by Nanning No.2 Pharmaceutical Factory to treat 40 cases of duodenal ulcer 40 times a day before bedtime (hereinafter referred to as one-time treatment) Cases of control, the observation is now reported as follows.