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目的评价原发性肝细胞癌(HCC)动脉内栓塞化疗(TACE)后CT形态学与生存率的相关性。资料与方法65例(病理诊断17例,临床诊断48例)HCC患者进行了264次TACE,药物为吡柔比星50mg/m2、艾恒/顺铂50mg/m2,碘化油5～20ml和明胶海绵颗粒。肝脏和肿瘤体积用体积测量软件获得,碘化油沉积情况在治疗后3～4周随访CT评价。结果肿瘤体积<200ml(P<0.001)、肿瘤与肝脏体积的比值<5%(P<0.001)、碘化油完全沉积(≥75%)(P<0.001)的患者生存率明显提高,弥漫性生长方式的肿瘤(P<0.001)、存在9个以上病灶(P<0.001)和病变累及三个肝段以上的患者生存率较差。结论原发性HCCTACE后CT形态学评价与生存率有密切的相关性,对临床治疗起着重要的指导作用。
Objective To evaluate the correlation between CT morphology and survival rate after primary hepatocellular carcinoma (HCC) arterial embolization (TACE). Materials and Methods TACE was performed in 65 patients (pathological diagnosis of 17 cases, clinical diagnosis of 48 cases) HCC patients carried 264 times, the drug was pirarubicin 50mg / m2, Aiheng / cisplatin 50mg / m2, iodized oil 5 ~ 20ml and Gelatin sponge particles. Liver and tumor volumes were obtained by volume measurement software and iodinated oil deposition was followed up at 3 to 4 weeks after treatment for CT evaluation. Results The survival rate of patients with tumor volume <200ml (P <0.001), tumor to liver volume ratio <5% (P <0.001) and iodinated oil complete deposition Growth-type tumors (P <0.001), with more than 9 lesions (P <0.001) and lesions involving more than three segments of the liver, had poorer survival rates. Conclusions CT morphological evaluation after primary HCCTACE is closely related to the survival rate, which plays an important guiding role in clinical treatment.