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目的:探讨自制造影剂和能量多普勒声学造影在诊断实验性转移性肝癌血管显像中的应用价值.方法:选用VX2肿瘤模型兔8只,利用HP5500彩色多普勒超声仪观察自制声学造影剂注射前后肿瘤病灶的二维回声特点,病灶周边和内部彩色多普勒与能量多普勒血流显示的变化、规律和特征.结果:二维超声检查发现8只兔共有12个病灶,病灶直径自1.6-4.8cm不等,回声特点表现多样缺乏特异性.CDFI和PDI显示,声学造影后兔肝内转移癌病灶周边及内部点状或条状血管数目增多,尤以PDI变化最为明显.血管形态改变明显,呈长条状有时可见分支,瘤体周边可见血流环绕,且血流信号清晰完整,甚至可见部分血管深入中心部分.低机械指数条件下的二次造影谐波成像能动态、实时和较长时间观察病灶,造影过程可分为四个时相即(1)下腔静脉相;(2)动脉相;(3)门静脉相;(4)肝实质相.动脉时相中肿瘤的滋养动脉显示清晰,瘤体内造影剂显影出现快,门脉相和肝实质相中,肿瘤显影快速消退,为典型的负显影.结论:低机械指数条件下的二次造影谐波成像与CDFI、PDI比较对肝脏转移性癌的部位、范围、血管特征的诊断具有更高的特异性和准确率.
Objective: To explore the value of self-made contrast medium and energy Doppler ultrasound in the diagnosis of experimental metastatic liver cancer angiography.Methods: 8 VX2 tumor model rabbits were selected, and the contrast of homemade contrast-enhanced ultrasound The characteristics of two-dimensional echocardiography before and after the injection of the agent, the changes, regularity and characteristics of peripheral and internal color Doppler and the energy Doppler flow were measured.Results: There were 12 lesions and 8 lesions Diameter ranging from 1.6-4.8cm, echo characteristics of the lack of specificity of the lack of specificity.CDFI and PDI showed intracavitary ultrasound lesion around the liver and internal spots or stromal vascular number increased, especially in the most obvious changes in PDI. The blood vessel morphology changes obviously, the long strip sometimes shows the branch, the periphery of the tumor can be seen around the blood flow, and the blood flow signal is clear and complete, and even some of the blood vessels can be seen in the central part.Secondary contrast harmonic imaging under the condition of low mechanical index can dynamically , Real-time and longer observation of lesions, the imaging process can be divided into four phases that (1) the inferior vena cava phase; (2) arterial phase; (3) portal vein phase; (4) of The nociceptive artery showed a clear appearance of contrast agent in the tumor appeared fast, portal phase and liver parenchyma, the rapid development of tumor imaging subsided, the typical negative development.Conclusion: Under the condition of low mechanical index second harmonic contrast imaging and CDFI, PDI has a higher specificity and accuracy in the diagnosis of metastatic liver cancer site, range, and vascular features.