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[目的]比较分析内镜黏膜下剥离术(ESD)与外科手术治疗早期胃癌(EGC)的临床疗效及预后。[方法]将EGC患者90例,随机分成ESD组(45例)和外科手术组(45例)。术后随访至少2年,比较2组手术的临床效果,出血、穿孔等并发症及预后情况。[结果]与外科手术组比较,ESD组的手术时间明显增加,住院时间、住院费用明显降低(P<0.05),但ESD组、外科手术组整块切除率(93.3%∶100.0%)、治愈性切除率(84.4%∶93.3%)比较均差异无统计学意义(P>0.05);ESD组手术并发症的发生率为8.9%,显著低于外科手术组的24.4%(P<0.05);术后1年、2年,ESD组与外科手术组生存率(100.0%∶100.0%)、(93.3%∶97.8%),复发率(0%∶0%)、(4.4%∶2.2%)比较均差异无统计学意义(P>0.05)。[结论]ESD对EGC的治疗与外科手术疗效及预后相当,且住院时间短、费用低、并发症少,
[Objective] To compare and analyze the clinical efficacy and prognosis of endoscopic submucosal dissection (ESD) and surgical treatment of early gastric cancer (EGC). [Methods] 90 patients with EGC were randomly divided into ESD group (45 cases) and surgical group (45 cases). The patients were followed up for at least 2 years. The clinical effects, bleeding and perforation complications and prognosis were compared between the two groups. [Results] Compared with the surgical group, the operation time of ESD group increased significantly, and the length of hospitalization and hospitalization significantly decreased (P <0.05). However, the resection rate of the ESD group and the surgery group was 93.3% and 100.0%, respectively The incidence of surgical complications in ESD group was 8.9%, which was significantly lower than that in surgical group (24.4%, P <0.05). There was no significant difference between the two groups (P> 0.05). Survival rate (100.0%: 100.0%), (93.3%: 97.8%), relapse rate (0%: 0%), (4.4%: 2.2%) in ESD group and surgery group at 1 year and 2 years after operation All the differences were not statistically significant (P> 0.05). [Conclusion] The treatment of EGC by ESD is equivalent to the curative effect and prognosis of surgery, and the hospitalization time is short, the cost is low, the complication is less,