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胆管癌是肝胆外科较为常见的恶性肿瘤,近年来随着医学影像诊断水平提高和人口寿命的延长,其发病率有上升趋势[1]。但因其复杂的发病机制及病理特征,临床手术治愈率低,其它抗癌辅助治疗效果亦不明显,因而预后较差[2]。近年来国内外针对胆管癌的基础和临床研究逐步增多[3],氧自由基已被证实与多种疾病的发生发展关系密切,现已探明肿瘤细胞中氧自由基其代谢产物明显高于正常组织,这些自由基是癌细胞内某些基因(如Ras等)生长信号传导途径的重要环节,可刺激肿瘤细胞分裂、增殖,进而影响细胞凋亡等代谢活动[4]。本文采用先进的紫外分光光度法等技术,检测了24例临床胆管癌标本中氧自由
Cholangiocarcinoma is a common malignant tumor in hepatobiliary surgery. In recent years, with the increase of diagnosis of medical imaging and prolongation of population lifespan, the incidence of cholangiocarcinoma is on the rise [1]. However, due to its complex pathogenesis and pathological features, the clinical cure rate is low, and other anti-cancer adjuvant therapy effect is not obvious, so the prognosis is poor [2]. In recent years, both basic and clinical researches on cholangiocarcinoma both at home and abroad have gradually increased [3]. Oxygen free radicals have been confirmed to be closely related to the occurrence and development of various diseases. It has been found that the metabolites of oxygen free radicals in tumor cells are significantly higher In normal tissues, these free radicals are important links in the growth signal transduction pathway of some genes in cancer cells (such as Ras), which can stimulate tumor cells to divide, proliferate and then affect metabolic activities such as apoptosis [4]. In this paper, advanced UV spectrophotometry and other techniques, detection of 24 cases of clinical cholangiocarcinoma oxygen free