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目的探讨海岛居民血清高敏C反应蛋白(high sensitive C-reactive protein,HS-CRP)浓度与高血压的关系。方法对119例原发性高血压患者和119例年龄、性别相匹配的正常对照者进行问卷调查,了解其一般情况及高血压家族史等相关信息,并测量血压,采集空腹静脉血测定血清HS-CRP、尿酸、血糖、胆固醇、甘油三酯等生化指标。比较病例组和对照组血清HS-CRP水平的差异,并用多因素Logistic回归模型分析高血压的危险因素。结果高血压组HS-CRP水平高于对照组,并且血压值随着HS-CRP水平的增加而增加。在高血压危险因素的单因素分析中,以第一分位HS-CRP为参比,第四分位血清HS-CRP是高血压的危险因素(OR=2.13,95%CI:1.03~4.37)。在校正其他因素影响后,血清HS-CRP与高血压无统计学关联。结论海岛居民中原发性高血压患者血清HS-CRP水平较正常对照者增高,但校正混杂因素后关联消失,提示血清HS-CRP可能不是高血压的一个独立危险因素。
Objective To investigate the relationship between serum high-sensitivity C-reactive protein (HS-CRP) and hypertension in island residents. Methods A total of 119 patients with essential hypertension and 119 age and sex matched controls were surveyed to find out the general situation and related information such as family history of hypertension. Blood pressure was measured and fasting venous blood -CRP, uric acid, blood glucose, cholesterol, triglycerides and other biochemical indicators. The difference of serum HS-CRP level between the case group and the control group was compared, and the risk factors of hypertension were analyzed by multivariate Logistic regression model. Results The level of HS-CRP in hypertension group was higher than that in control group, and the blood pressure increased with the increase of HS-CRP level. In the univariate analysis of risk factors for hypertension, HS-CRP in the fourth quintile was the risk factor for hypertension (OR = 2.13, 95% CI: 1.03 to 4.37) . No significant correlation was found between serum HS-CRP and hypertension after adjusting for other factors. Conclusion The serum levels of HS-CRP in patients with essential hypertension in island residents are higher than those in normal controls. However, the association disappears after the confounding factors are corrected, suggesting that serum HS-CRP may not be an independent risk factor for hypertension.