治疗疾病的药物,大多数可以看作是弱酸或弱碱。它们在溶液中可发生解离,其解离程度的大小与药物的 pKa 及溶液 pH 有关。三者之间的函数关系,可用Henderson—Hasselbalch 方程(简称 HH 方程) Most of the drugs used to treat the disease can be regarded as weak acids or weak bases. They can dissociate in solution, the degree of dissociation depends on the drug pKa and solution pH. The functional relationship between the three available Henderson-Hasselbalch equation (referred to as HH equation)