细胞周期相关激酶(cell cycle-related kinase,CCRK)是新近发现的一种细胞周期蛋白依赖性激酶活化激酶(CDK-activating kinase,CAK),在多种恶性肿瘤细胞中伴有CCRK过表达,CCRK能促进细胞增殖引起恶性肿瘤的发生发展,而抑制CCRK基因能使肿瘤细胞周期停滞、细胞克隆形成率和增殖活性降低。CCRK参与的信号通路与癌症的成因与演变有关。现就CCRK与肿瘤易感相关性研究作一综述。 Cell cycle-related kinase (CCRK) is a newly discovered CDK-activating kinase (CAK), which is associated with CCRK overexpression in a variety of malignant tumor cells. CCRK Can promote cell proliferation caused by the occurrence and development of malignant tumors, and inhibition of CCRK gene can make tumor cell cycle arrest, cell cloning formation rate and proliferation activity decreased. The pathways involved in CCRK are related to the causes and evolution of cancer. Now on CCRK and tumor susceptibility to make a review of the study.