自发现消炎痛具有抑制前列腺素合成的作用以来，该药的临床应用范围不断拓宽，其不良反应的发生率亦随之增加，文献报道高达35％～50％。近年来陆续报道了消炎痛一些特殊不良反应，观介绍如下。1心血管系统黄文益[1]报告3例上感患儿．基础血压正常，口服常现剂量消炎痛，半小时 Since the discovery of indomethacin inhibits the role of prostaglandin synthesis, the clinical scope of the drug continues to broaden, the incidence of adverse reactions also increased, reported in the literature up to 35% to 50%. In recent years, one after another reported some special side effects of indomethacin, the concept described below. 1 cardiovascular system Huang Wenyi [1] reported 3 cases of children. Normal blood pressure, oral administration of normal dose of indomethacin, half an hour