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合并感染人类T淋巴细胞I型病毒（HILV－1）和HIV病毒的病例中，存在HIV疾病进程标志物和临床病期分离的现象。据观察，合并感染HTLV－1不仅不影响HIV病毒载量，而且目前认为它是HIV疾病进程最好的标志物。作者检测了23例合并感染者及99例单独HIV感染者储存血清的HIVRNA水平，并分析其与CD4+淋巴细胞计数的关系。病例从巴西里约热内卢正在进行的一项队列研究中抽取，两组结果均显示：CD4+淋巴细胞计数随HIVRNA水平升高而降低。以直线回归法校正血清HIVRNA水平后发现，合并感染者CD4+淋巴细胞计数比那些单独HIV感染者约高78％。问样对β2-微球蛋白水平校正后，也有相似结果，即合并感染者CD+4计数比单独HIV感染者高146％（P=0.005，95％CI：32％到359％）。这些数据表明，合并感染者中发现较高的CD4+淋巴细胞计数并不表示免疫学功效，而可能反映了与HTLV－1有关的非特异性淋巴细胞增生的情况。本文及其它研究说明，CD4+计数作为HIV感染临床诊断的一种简捷方法，可能并不适用于上述合并感染中。相对于HIV单独感染，HIV病毒数量可能更适于作为合并感染的代替标志物。
In the case of co-infection with human T lymphocyte type I virus (HILV-1) and the HIV virus, there was a separation of HIV disease progression markers and clinical stage. It has been observed that coinfection of HTLV-1 not only does not affect the HIV viral load but is currently considered to be the best marker of HIV disease progression. The authors examined the HIV RNA levels of 23 pooled patients and 99 HIV infected individuals and analyzed their association with CD4 + lymphocyte counts. The cases were drawn from an ongoing cohort study in Rio de Janeiro, Brazil. Both results showed that CD4 + lymphocyte counts decreased with increasing HIV RNA levels. Using linear regression to correct serum HIV RNA levels, CD4 + lymphocyte counts in co-infected individuals were found to be about 78% greater than those with HIV alone. There was also a similar result after the β2-microglobulin level was corrected for the sample, which is 146% higher for CD + 4 co-infected individuals than for HIV-infected individuals alone (P = 0.005, 95% CI: 32% to 359%). These data suggest that higher CD4 + lymphocyte counts found in co-infected patients do not indicate immunological efficacy and may reflect non-specific lymphoproliferation associated with HTLV-1. This and other studies suggest that CD4 + counts as a simple and straightforward method of clinical diagnosis of HIV infection may not be suitable for the above co-infections. The number of HIV viruses may be more suitable as an surrogate marker of co-infection than HIV alone.