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对114例重症镇静催眠药中毒、急性酒精中毒病人分两组治疗。纳洛酮（NLX）治疗组56例，24h内清醒41例（占73.2％）；常规治疗组58例，24h内清醒20例（占34．5％），两组比较有非常显著性差异（P＜0．01）。证实NLX救治镇静催眠药中毒、乙醇中毒疗效确切，催醒时间短、用药安全。
114 cases of severe sedation hypnosis poisoning, acute alcoholism patients were divided into two groups. There were 56 cases in naloxone group (NLX) and 41 cases (73.2%) in 24 hours, 58 cases in conventional treatment group and 20 cases (34.5%) in 24 hours. There was significant difference between the two groups P <0.01). Confirmed NLX treatment of sedation hypnosis poisoning, ethanol poisoning curative effect, reminder time is short, medication safety.