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糖尿病肾病(diabetic nephropathy,DN)是糖尿病(diabetes mellitus,DM)的常见的慢性微血管并发症之一。慢性高糖状态下糖基化终末产物(AGEs)形成增加,诱导肾脏氧化应激和内质网应激,参与糖尿病肾病的发生与发展。二甲双胍是目前临床治疗糖尿病的最常用药物之一。越来越多的研究表明,二甲双胍除了最主要的降糖作用外,其尚可抑制AGEs形成和具有抗氧化作用,深入研究AGEs与DN的关系,有助于进一步了解DN的发病机制并对干预其发生和发展具有重要的指导意义。
Diabetic nephropathy (DN) is one of the common chronic microvascular complications of diabetes mellitus (DM). The formation of advanced glycation end products (AGEs) in chronic high glucose conditions induces oxidative stress in kidney and endoplasmic reticulum stress, which is involved in the occurrence and development of diabetic nephropathy. Metformin is currently one of the most commonly used drugs for the clinical treatment of diabetes. More and more studies have shown that metformin in addition to the main hypoglycemic effect, it can inhibit the formation of AGEs and have antioxidant effects, in-depth study of the relationship between AGEs and DN helps to further understand the pathogenesis of DN and intervention Its occurrence and development have important guiding significance.