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目的:分析医院临床以氟喹诺酮类药物为基础的抗菌药物联用的药物不良反应(ADR)发生情况,为提高用药方案的安全性提供参考。方法:选取2014年1—12月期间使用氟喹诺酮类药物为基础的抗菌药物联用治疗的137例上报ADR报告的患者作为本组研究的观察对象,分析ADR发生患者的性别、年龄分布和临床表现,以及用药途径和药物类别的构成情况。结果:(1)137例ADR患者中,男患者占54.73%,女患者占45.27%;20~59岁患者为77例占56.21%;(2)ADR临床表现以皮肤及附件反应占34.31%,其次为消化系统反应占29.21%;(3)给药途径以静脉注射为主占91.24%;(4)ADR所涉及的药物主要以左氧氟沙星为主,占81.75%。结论:要加强氟喹诺酮类药物ADR的监测,预防ADR的发生,提高氟氟喹诺酮类药物使用的安全性。
OBJECTIVE: To analyze the incidence of adverse drug reaction (ADR) in hospital based on fluoroquinolone antibacterials and to provide references for improving the safety of the medication regimen. METHODS: A total of 137 ADR-reported patients treated with fluoroquinolone-based antibacterials during January-December 2014 were selected as subjects in this study to analyze the gender, age distribution and clinical status of patients with ADR Performance, as well as the route of administration and the composition of the drug category. Results: (1) In 137 ADR patients, male patients accounted for 54.73%, female patients accounted for 45.27%, while patients aged 20- 59 accounted for 56.21%. (2) The clinical manifestations of ADR were skin and accessory reactions accounting for 34.31% Followed by digestive system reaction accounted for 29.21%; (3) route of administration of intravenous injection accounted for 91.24%; (4) ADR involved mainly levofloxacin drugs, accounting for 81.75%. Conclusion: To strengthen the monitoring of fluoroquinolone ADR, prevent the occurrence of ADR and improve the safety of fluoroquinolones.