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目的:分析医院药品不良反应发生的特点和相关因素,为临床合理用药,促进药品不良反应报告监测工作的开展提供参考。方法:抽取2016年1—12月间上报的207例药品不良反应报告,按照患者年龄、药品类型、不良反应涉及系统、给药途径等进行统计和分析。结果:上报的207例报告中涉及药品不良反应的药品有70种,其中抗菌药物发生95例占45.89%居首位,静脉给药引发的药品不良反应196例占94.69%;药品不良反应的临床表现主要以注射部位损害以及血管炎、消化系统不适(恶心、呕吐为主)。结论:通过207例ADR的分析,掌握了ADR发生的规律,以避免和减少药品不良反应的发生,为临床合理用药及药物安全性评价提供依据。
OBJECTIVE: To analyze the characteristics and related factors of hospital adverse drug reactions and provide references for the clinical rational use of drugs and the promotion of monitoring reports of adverse drug reactions. Methods: A total of 207 adverse drug reactions reported in January-December 2016 were collected and analyzed according to patient’s age, type of drug, system involved in adverse reactions, route of administration and so on. Results: Of the 207 reported cases, 70 kinds of drugs were involved in ADRs, of which 95 cases accounted for 45.89% of antimicrobial drugs, 196 cases accounted for 94.69% of the adverse drug reactions caused by intravenous administration. Clinical adverse drug reactions Mainly to the injection site damage and vasculitis, digestive discomfort (nausea, vomiting). Conclusion: Through the analysis of 207 cases of ADR, the regularity of occurrence of ADR was grasped to avoid and reduce the occurrence of adverse drug reactions and provide basis for clinical rational drug use and drug safety evaluation.