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目的了解阻塞性黄疸病人术前术后免疫机能变化情况。方法检测20例非黄疸性疾病病人，17例良性阻塞性黄疸病人，16例恶性阻塞性黄疸病人手术前后血清可溶性白细胞介素─2受体水平。结果术前良、恶性阻塞性黄疸病人血清可溶性白细胞介素-2受体水平高于非黄疸性疾病组（P＜0．01）。阻塞性黄疸病人减黄手术后血清可溶性白细胞介素-2受体表现为升高，于术后第4天开始下降，至第14天良性阻塞性黄疸组降至比术前低，而恶性阻塞性黄疸组于术后有一短暂的下降期后则进一步升高。结论表明减黄手术对良性阻塞性黄疽疾病有改善免疫功能作用，对恶性阻塞性黄疸疾病则无改善免疫功能的作用。
Objective To understand the preoperative and postoperative immune function changes in patients with obstructive jaundice. Methods Twenty patients with non-jaundice disease, 17 patients with benign obstructive jaundice and 16 patients with malignant obstructive jaundice before and after operation were measured serum soluble interleukin-2 receptor levels. Results The levels of serum soluble interleukin-2 receptor in patients with benign and malignant obstructive jaundice before operation were significantly higher than those without jaundice (P <0.01). In patients with obstructive jaundice, serum soluble interleukin-2 receptor (IL-2R) was increased after the operation of reducing yellow, and began to decline on the 4th day after operation. On the 14th day, the group of benign obstructive jaundice decreased to lower than preoperative and malignant obstruction The jaundice group was further elevated after a brief period of decline. The results show that yellowing surgery has the effect of improving immune function in patients with benign obstructive jaundice, and has no effect on immune function in patients with malignant obstructive jaundice.