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目的揭示胆囊收缩素(CCK)在冠状动脉粥样硬化斑块中的表达情况,以进一步探讨CCK在动脉粥样硬化形成过程中的作用。方法选用100例35～92岁男性尸检冠状动脉粥样硬化标本,分为粥样硬化Ⅰ～Ⅱ级组和Ⅲ～Ⅳ级组,同时设正常对照组,用免疫组化技术进行检测。结果对照组CCK呈阴性表达,而冠状动脉粥样硬化组呈阳性表达(P<0.01),Ⅰ～Ⅱ级组与Ⅲ～Ⅳ级组之间CCK表达无显著差异(P>0.05)。结论 CCK在冠状动脉粥样硬化斑块中的有表达,但不随粥样硬化斑块程度的变化而变化。
Objective To reveal the expression of cholecystokinin (CCK) in atherosclerotic plaque and to further explore the role of CCK in the development of atherosclerosis. Methods A total of 100 coronary atherosclerotic specimens from 35 to 92 years of age were selected and divided into group Ⅰ ~ Ⅱ and group Ⅲ ~ Ⅳ of atherosclerosis. Meanwhile, a normal control group was also established. Immunohistochemistry was used for detection. Results The expression of CCK in the control group was negative and that in the coronary atherosclerosis group was significantly higher than that in the control group (P <0.01). There was no significant difference in CCK expression between Ⅰ ~ Ⅱ group and Ⅲ ~ Ⅳ group (P> 0.05). Conclusions CCK is expressed in coronary atherosclerotic plaques, but not with the degree of atherosclerotic plaques.