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地方性砷中毒是一种严重危害健康的地方病,研究发现,高砷暴露环境下的个体并不都患病,提示除环境因素外,个体的遗传易感性在砷中毒的发病过程中可能也起着重要作用。砷在体内的代谢过程涉及许多酶促和/或非酶促反应过程,现在研究较多的砷代谢酶促反应3种相关酶是谷胱甘肽S转移酶(GSTO 1-1)、嘌呤核苷磷酸化酶(PNP)、三价砷甲基转移酶(CYT19/AS3MT),围绕上述酶及其基因多态性展开综述。
Endemic arsenism is a endemic disease that seriously endangers health. Studies have found that individuals not exposed to high levels of arsenic are not always affected, suggesting that in addition to environmental factors, the individual’s genetic predisposition may also play a role in the pathogenesis of arsenicosis An important role. Arsenic metabolism in the body involves many enzymatic and / or non-enzymatic processes, and now more studies of the three enzymes involved in arsenic metabolism enzymatic reactions are glutathione S-transferase (GSTO 1-1), purine nuclei Glycosidase (PNP), trivalent arsenic methyltransferase (CYT19 / AS3MT), around the above enzymes and their genetic polymorphisms are reviewed.