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合成5-甲基-2-丙酰呋喃与氨的乙醇或水溶液于170℃～180℃反应10～12小时即得本品。〔DE 3330053;FR 2551659;JP8561526;US 4486440〕药理作用本品是一个水溶性的抗氧剂,是维生素B_6族化合物的结构类似物。抗氧作用是由于分子中存在酚羟基。本品具有广泛的药理作用,能有效地抑制生物膜脂质的自由基氧化,有效地稳定膜结构,尤其是血细胞(红细胞、血小板)膜结构,有效地抑制循环核蛋白的磷酸二酯酶,提高cAMP的浓度,有效地抑制血小板的体内
Synthesis of 5-methyl-2-propionyl furan and ammonia in ethanol or water at 170 ℃ ~ 180 ℃ for 10 to 12 hours to obtain the goods. [DE 3330053; FR 2551659; JP8561526; US 4486440] Pharmacological effects This product is a water-soluble antioxidant, is a structural analogues of vitamin B_6 compounds. The antioxidant effect is due to the presence of phenolic hydroxyl groups in the molecule. This product has a wide range of pharmacological effects, can effectively inhibit the biofilm lipid free radical oxidation, effectively stabilizing the membrane structure, especially the blood cells (red blood cells, platelets) membrane structure, effectively inhibit circulating nucleoprotein phosphodiesterase, Increase the concentration of cAMP, effectively inhibiting platelet in vivo