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目的观察射频消融治疗对肝癌患者外周血细胞T淋巴细胞计数的影响,探讨射频消融治疗对机体免疫功能的影响。方法随机选取30例行肝癌射频消融治疗的患者,分别于射频消融治疗前1d、治疗后14d和28d检查外周血CD4+、CD8+、CD3+、CD4+/CD8+比值,观察射频消融前后水平变化。结果 RFA后14dCD4+为36.48±10.21,CD8+为24.58±11.08;28dCD4+为37.10±10.86,CD8+为23.69±11.47,与术前CD4+(27.58±9.53)、CD8+(31.25±10.32)比较均有显著性差异,P<0.05。结论 RFA治疗后患者免疫功能得到显著改善,可能对肝癌患者的预后起到重要作用。
Objective To observe the effect of radiofrequency catheter ablation on the count of peripheral blood T lymphocytes in patients with hepatocellular carcinoma (HCC) and explore the effect of radiofrequency catheter ablation on immune function. Methods Totally 30 patients undergoing radiofrequency ablation of liver cancer were randomly selected. The levels of CD4 +, CD8 +, CD3 + and CD4 + / CD8 + in peripheral blood were examined at 1 day before radiofrequency ablation, 14 days and 28 days after radiofrequency ablation respectively. Results After 14 days of RFA, the CD4 + was 36.48 ± 10.21 and the CD8 + was 24.58 ± 11.08. The CD8 + was 37.10 ± 10.86 and 23.69 ± 11.47 on the 28th day after RFA, which was significantly different from the preoperative CD4 + (27.58 ± 9.53) and CD8 + (31.25 ± 10.32) P <0.05. Conclusion The immune function of patients after RFA has been significantly improved, which may play an important role in the prognosis of patients with liver cancer.