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目的探讨钙卫蛋白（S100A8／A9）在急性心肌梗死（Acute myocardial infarction ，AMI）患者血清中的水平以及与患者近期预后的关系。方法收集2012年3月至2013年3月在本院诊治且病历资料完整的AMI患者64例，稳定型心绞痛（SAP组）30例，另选择健康体检者（NC组）30例作为对照组。收集研究对象的一般情况，血生化指标；检测各组入院时空腹血清S100A8／A9水平，出院后3个月对AM I患者进行电话随访，了解患者的近期预后。结果 AMI组的血清S100A8／A9水平明显高于 SAP组、健康对照组（ P ＜0．05）；SAP组S100A8／A9水平亦高于健康对照组（ P ＜0．05）；S100A8／A9、空腹血糖（FPG）、吸烟以及高胆固醇血症影响 AMI患者的近期预后（死亡或因心脏事件再住院）（ P ＜0．05）。结论 AMI患者血清S100A8／A9水平显著升高；血清S100A8／A9与AMI患者的近期预后相关。“,”[Objective]To explore the correlation between serum calprotectin(S100A8/A9) and short‐term prognosis in patients with acute myocardial infarction(AMI) .[Methods]A total of 64 AMI patients and 30 pa‐tients with stable angina pectoris(SAP group) who had intact clinical data and diagnosed in our hospital from March 2012 to March 2013 were collected .Other 30 healthy subjects(NC) were chosen as control group .Gen‐eral condition and biochemical indicators of all subjects were collected .Serum level of fasting S100A8/A9 in each group at admission was detected .Patients with AMI at 3 months after discharge were followed up by phone so as to understand the short‐term prognosis of patients .[Results] Serum level of S100A8/A9 in AMI group was obviously higher than that in SAP group and healthy control group( P <0 .05) ,and that in SAP group was also higher than that in healthy control group( P <0 .05) .Short‐term prognosis(death or rehospi‐talization due to cardiac event) of patients with AMI was affected by S100A8/A9 ,FPG ,smoking and hyper‐cholesterolemia( P <0 .05) .[Conclusion]Serum level of S100A8/A9 in patients with AMI is significantly ele‐vated ,and related with the short‐term prognosis of patients with AMI .