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Angew.Chem.Int.Ed.2015,54,897~900三氟甲硫基(CF3S)是强吸电子和最强亲脂基团,因此含三氟甲硫基的化合物在药物和农药研制中有着广泛的应用.近二年来,发展向有机分子引入三氟甲硫基是继三氟甲基化反应后有机氟化学领域的热点研究课题之一,但目前的工作主要集中于芳基三氟甲硫醚化合物的合成.中国科学院上海有机化学研究所卿凤翎课题组发展了醇的直接脱羟三氟甲硫基化反应.三氟甲硫基负离子不稳定,它会分解生成硫氟光气A和氟负离子.卿凤翎等认为新生成的
Angew.Chem.Int.Ed.2015,54,897 ~ 900 Trifluoromethylthio (CF3S) is a strong electron-withdrawing and the most lipophilic group, so trifluoromethylthio-containing compounds are widely used in the development of pharmaceuticals and pesticides The introduction of trifluoromethylsulfenyl to organic molecules in the recent two years is one of the hot research topics in the field of organofluorine chemistry after trifluoromethylation.However, the current work mainly focuses on aryl trifluoromethylsulfide Ether compounds .Chinese Academy of SciencesShanghai Institute of Organic ChemistryQing Feng Ling research group developed a direct alcohol dehydroxylation of thiosulfate.Trifluoromethylthio anion instability, it will decompose to generate sulfur phosgene A And fluorine anion. Qing Feng Ling, etc. that the new generation