早在20世纪40年代,基于对生物发育的研究,英国的生物学家沃丁顿(Waddington)创造性地提出了表观遗传学概念,其间苏黎世的生物学家哈多恩(Hadorn)也同样对生物发育的遗传进行了广泛而深入地研究。两个人工作的重要之处在于,将基因及基因的行为与生物发育的关系进行了非常有益的探索研究。他们都发现了这样一个事实:发育过程中,分化了的细胞能够在细胞分裂传代过程中保持其特有的表型不变。也就是说,决定该分化细胞特有表型的 As early as the 1940s, based on the study of biological development, the British biologist Waddington creatively put forward the concept of epigenetics. In the meantime, Zurich biologist Hadorn also said The genetics of biological development have been extensively and deeply studied. What’s important about the work of both people is that they have very useful exploration and research on the relationship between gene and gene behavior and biological development. They all found the fact that, during development, differentiated cells retain their characteristic phenotype during cell division and passage. That is, the unique phenotype of the differentiated cell is determined