目的:旨在探讨婴幼儿肺炎支原体肺炎(MPP)急性期与恢复期免疫功能及炎症因子变化及其临床意义。方法:选取MPP急性期患儿60例为研究对象及同期30例健康儿童为对照组,抽血以免疫散射比浊法检测免疫球蛋白(IgM、IgG、IgA)及补体C3、C4,ELISA法检测肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、白细胞介素13(IL-13)。结果:MPP急性期患儿IgM、C3较恢复期患儿及对照组均升高(P<0.05),MPP恢复期患儿IgG较急性期及对照组升高(P<0.05);MPP急性期及恢复期患儿IgA均较对照组下降(P<0.05),MPP急性期及恢复期患儿C4均较对照组升高(P<0.05),急性期高于恢复期(P<0.05);MPP急性期患儿TNF-α、IL-10、IL-13较恢复期患儿及对照组均升高(P<0.05),MPP恢复期较对照组升高(P<0.05),MPP急性期患儿IL-8较恢复期及对照组升高(P<0.05)。结论:婴幼儿MPP感染急性期及恢复期患儿免疫功能均存在紊乱及炎症因子表达异常,提示免疫调节失控及机体炎症反应变化明显。 Objective: To investigate the changes of immune function and inflammatory cytokines in acute and convalescent stage of infant pneumonia mycoplasma pneumonia (MPP) and its clinical significance. Methods: Sixty children with acute MPP were selected as experimental group and 30 healthy children at the same period as control group. Immunoglobulin (IgM, IgG, IgA), complement C3 and C4 Tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10) and interleukin-13 (IL- Results: The levels of IgM and C3 in the acute phase of MPP were significantly higher than those in the recovery group and the control group (P <0.05). The IgG in the MPP recovery group was higher than that in the acute phase and the control group (P <0.05) (P <0.05). The levels of C4 in both acute and convalescent MPP groups were higher than those in control group (P <0.05), and those in acute phase were higher than those in convalescent group (P <0.05). The levels of TNF-α, IL-10 and IL-13 in children with acute MPP were significantly higher than those in control group and recovery group (P <0.05) Children with IL-8 recovery and control group increased (P <0.05). Conclusion: The immune function of infants and young children with MPP infection in acute and convalescent stages are both abnormal and the expression of inflammatory cytokines is abnormal, which indicates that immune regulation is out of control and the inflammatory response changes obviously.