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目的探讨坐骨海绵体肌损伤性勃起功能障碍的修复治疗效果。方法选用生殖期雄性Wistar大鼠150只,采用抓阄法随机分为修复组1(n=30)、修复组2(n=30)、修复组3(n=30)、修复组4(n=30)、未修复组(n=10)、假手术组(n=10)及正常组(n=10)。修复组1切断双侧坐骨海绵体肌后立即将其缝合,修复组2、3、4分别在切断双侧坐骨海绵体肌后2、4、8周重新缝合切断的双侧坐骨海绵体肌,未修复组切断双侧坐骨海绵体肌后不作修复,正常组不做手术及修复处理。假手术组模拟手术操作过程,但不切断双侧坐骨海绵体肌。选用育龄期未孕雌性Wistar大鼠150只,采用抓阄法随机与上述各组一一配对饲养,观察2～4个月,了解各组雌鼠受孕情况。通过雌鼠受孕间接推断其配对雄鼠勃起功能恢复。结果修复组1雄鼠死亡3只,有效配对雌鼠27只,17只受孕,受孕率63.0%;修复组2雄鼠死亡6只,有效配对雌鼠26只,16只受孕,受孕率61.5%;修复组3雄鼠死亡5只,有效配对雌鼠26只,15只受孕,受孕率57.7%;修复组4雄鼠死亡9只,有效配对雌鼠23只,14只受孕,受孕率60.9%;未修复组雄鼠死亡1只,有效配对雌鼠9只,均未受孕;正常组与假手术组无死亡,配对雌鼠10只,均受孕。正常组与假手术组雌鼠受孕情况比较差异无统计学意义(P>0.05),正常组与未修复组及各修复组比较差异有统计学意义(P<0.05),假手术组与未修复组及各修复组比较差异有统计学意义(P<0.05),未修复组与各修复组比较差异有统计学意义(P<0.05),而各修复组之间两两比较差异无统计学意义(P>0.05)。结论修复切断的雄鼠双侧坐骨海绵体肌能改善勃起功能障碍,但与修复时间选择关系不大。
Objective To investigate the repair and treatment of erectile dysfunction caused by ischial cavernous muscles. Methods 150 male Wistar rats were randomly divided into three groups: n = 30, n = 30, n = 30, n = 30 and n = 30), uncorrected group (n = 10), sham operation group (n = 10) and normal group (n = 10). In the repair group 1, the bilateral ischial sponge muscles were severed immediately after sutured. The repair groups 2, 3 and 4 were re-sutured and resected the bilateral ischial sponges muscles 2, 4 and 8 weeks after the bilateral ischial sponges were excised, The uncoated group did not repair bilateral ischial sponge muscle, and the normal group did not undergo surgery and repair. The sham-operated group simulated the surgical procedure, but did not cut the bilateral ischial cavernous muscle. A total of 150 female Wistar rats of childbearing age were selected and randomly allocated to each of the above groups for one to two months and observed for 2 to 4 months to understand the pregnancy status of each group of female rats. Indirect inference of females from their maternal pregnancy induces erectile function recovery in male males. Results In the repair group, 3 males died, 27 mated females, 17 pregnant females and 63.0% pregnant females. Six males died in the repair group, 26 females were mated effectively, 16 females were pregnant and the pregnancy rate was 61.5% ; Repair group 3 males killed 5, effective mated females 26, 15 conception, pregnancy rate 57.7%; repair group 4 males died 9, mated effectively females 23, 14 conception, pregnancy rate 60.9% ; One non-repaired group died of males, 9 males effectively matched, all of which were not conceptioned. There were no deaths in the normal group and sham-operated group, and 10 females were pregnant. There was no significant difference in the pregnancy status between the normal group and the sham operation group (P> 0.05). The difference between the normal group and the uncorrected group and each repair group was statistically significant (P <0.05) There was significant difference between the two groups (P <0.05). There was significant difference between the two groups (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion Repair of bilateral male islets of the ischial muscle can improve erectile dysfunction, but has little to do with the choice of repair time.