作者报道了22例成骨肉瘤使用大剂量氨甲喋呤治疗后无症状病人脑的MR信号异常。22例中1例发现有脑白质的异常后,便对其余21例患成骨肉瘤并且至少接受4个疗程氨甲喋呤治疗的病人作了脑的MRI,这些病人均未做过脑的放射治疗或鞘内给予氨甲喋呤,均无神经系统症状。对照组是10例接受顺铂化疗的睾丸癌病人。根据Rosen等制定的T-10标准,成骨肉瘤病人术前后均作了化疗。氨 The authors reported abnormal MR signals in the brain of asymptomatic patients in 22 osteosarcoma patients treated with high-dose methotrexate. One of 22 patients with abnormalities of white matter was found to have MRI of the brain in the remaining 21 patients with osteosarcoma and at least 4 courses of methotrexate, none of whom underwent brain radiotherapy or sheathing Intra-methotrexate, no neurological symptoms. Control group was 10 cases of testicular cancer patients receiving cisplatin chemotherapy. According to Rosen and other standards developed by T-10, osteosarcoma patients were treated before and after chemotherapy. ammonia