大环内酯类抗生素自上市以来一直用于治疗呼吸系统等疾病,但随着该类药物的广泛应用,耐药菌日益增多。为此,研究者们一直致力于半合成大环内酯类抗生素的研究,希望开发出对耐药菌有效、抗菌谱广的半合成衍生物。综述近年来对大环内酯9位羰基结构修饰的研究进展,并着重介绍一些活性较好的化合物。 Macrolide antibiotics have been used to treat diseases such as the respiratory system since they were introduced to the market. However, with the wide application of these drugs, the number of drug-resistant bacteria has been increasing. To this end, researchers have been committed to semi-synthetic macrolide antibiotics, hoping to develop effective for antibacterial bacteria, antibacterial broad spectrum of semi-synthetic derivatives. In recent years, the research progress on the carbonyl structural modification of 9-position macrocyclic lactone is reviewed. Some compounds with good activity are also introduced emphatically.