非洲裔美国人较可能发生高血压和高血压性肾硬化。终末期肾脏疾病(end-stage renal disease,ESRD)的预后极差,再加上该疾病在黑人中的家族聚集性,促使研究者探索ESRD的遗传风险因子。最近有证据显示交感神经系统在肾脏疾病进展中具有重要作用。方法 :研究者使用非洲裔美国人肾脏疾病研究项目的资料,以探索β2肾上腺素能受 African Americans are more likely to develop hypertension and hypertensive nephrosclerosis. The poor prognosis of end-stage renal disease (ESRD), combined with familial clustering of the disease in blacks, prompted the investigators to explore the genetic risk factors for ESRD. There is recent evidence that the sympathetic nervous system plays an important role in the progression of kidney disease. METHODS: Investigators used data from the African American Kidney Disease Research Project to explore the role of β2 adrenergic receptor