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目的:探讨IgA肾病患者血清中瘦素(leptin)水平变化的特点及其临床意义。方法:选取40例IgA肾病患者,按照是否需要透析治疗标准划分为A组(无需透析治疗)、B组(需长期透析治疗)及C组(健康体检者),每组各20例(n=20)。收集晨起空腹血清(B组外加透析前后的血清),采用竞争性放射免疫分析法(RIA)检测leptin的水平并分析其临床意义。结果:A、B、C组血清leptin的平均水平分别为(4.98±0.78)μg/L、(6.45±0.76)μg/L及(3.96±0.56)μg/L。A、B组血清leptin的平均水平显著高于正常对照C组(P<0.05);B组血清Leptin的平均水平明显高于A组(P<0.05);B组患者透析前后血清leptin的平均水平分别为(6.50±0.86)μg/L及(5.21±0.66)μg/L,透析后血清leptin的平均水平显著低于透析前(P<0.05)。结论:IgA肾病患者存在血清leptin的水平明显升高,血液透析能降低其血清水平,提示leptin可能在IgA肾病发生发展中起着重要的作用。
Objective: To investigate the changes of serum leptin level in patients with IgA nephropathy and its clinical significance. Methods: Forty patients with IgA nephropathy were divided into group A (without dialysis treatment), group B (requiring long-term dialysis treatment) and group C (healthy subjects) according to the criteria of dialysis treatment, 20 patients in each group (n = 20). The morning fasting serum was collected (before and after the dialysis group B plus serum), the level of leptin was detected by competitive radioimmunoassay (RIA) and its clinical significance was analyzed. Results: The mean levels of leptin in A, B and C groups were (4.98 ± 0.78) μg / L, (6.45 ± 0.76) μg / L and (3.96 ± 0.56) μg / L, respectively. The average level of leptin in group A and group B was significantly higher than that in group C (P <0.05); the average level of Leptin in group B was significantly higher than that in group A (P <0.05); The level of serum leptin in group B was significantly higher than that in group C (6.50 ± 0.86) μg / L and (5.21 ± 0.66) μg / L, respectively. The mean serum leptin level after dialysis was significantly lower than that before dialysis (P <0.05). Conclusion: Serum leptin levels are significantly elevated in patients with IgA nephropathy, hemodialysis can reduce serum levels, suggesting that leptin may play an important role in the development of IgA nephropathy.