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截肢患者中50%-80%经历过幻肢疼痛。前扣带回(anterior cingulate cortex,ACC)是参与疼痛情绪反应形成的一个重要部位。为揭示前扣带回在幻肢疼痛中的作用,我们采用成年大鼠右后中趾截除慢性疼痛模型,麻醉固定后在体纪录大脑前扣带回锥体神经元之间突触传递特性的变化。所记录神经元经形态学确认为前扣带回锥体神经元。结果显示,在右后中趾截除后3-7d,大鼠前扣带回锥体神经元兴奋性突触后电位持续性增强,同时,反映突触前机制参与突触可塑性的配对脉冲易化(paired-pulse facilitation,PPF)值增大。结果表明,大鼠在体脚趾截除引起前扣带回锥体神经元兴奋性突触后电位持续性增强,这个增强的突触传递可能参与了幻肢疼痛的形成过程。
50% -80% of amputees experience phantom limb pain. Anterior cingulate cortex (ACC) is involved in the formation of an important part of the emotional response to pain. In order to reveal the role of anterior cingulate gyrus in the phantom limb pain, we used the right middle toe of adult rats to cut off the chronic pain model and record the synaptic transmission characteristics of anterior cingulate pyramidal neurons The change. The recorded neurons were morphologically identified as anterior cingulate pyramidal neurons. The results showed that the excitatory postsynaptic potentials of anterior cingulate pyramidal neurons in rats were continuously increased 3-7 days after the right middle-toe amputation was cut, and at the same time, the paired pulses that reflect the presynaptic mechanisms involved in synaptic plasticity Paired-pulse facilitation (PPF) values increase. The results showed that the amputation of the toes in rats caused a sustained increase of the excitatory postsynaptic potential of anterior cingulate pyramidal neurons. This enhanced synaptic transmission may be involved in the formation of phantom limb pain.