1.糖尿病流行病学及其治疗糖尿病是世界第三大疾病,可分为胰岛素依赖型(Ⅰ型,即IDDM)糖尿病和非胰岛素依赖型(Ⅱ型,即NIDDM)糖尿病,我国约4000万糖尿病患者中,90%以上为Ⅱ型糖尿病患者。目前对于Ⅰ型糖尿病的治疗,研究方向是开发给药方便、有效的胰岛素制剂及代用品。H型糖尿病的主要病因是胰岛素抗性,传统治疗药物有磺酰脲类、非磺酰脲类。 1. Diabetes epidemiology and its treatment Diabetes is the third largest disease in the world and can be divided into insulin-dependent (type I, IDDM) diabetes and non-insulin-dependent (type II, or NIDDM) diabetes mellitus, about 40 million diabetes mellitus More than 90% of patients are Type II diabetic patients. Currently for the treatment of type 1 diabetes, the research direction is to develop convenient and effective administration of insulin preparations and substitutes. H-type diabetes is the main cause of insulin resistance, the traditional treatment of sulfonylurea drugs, non-sulfonylureas.