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Objective To investigate the inhibitory effect of photodynamic on keloid by observing the changes of various indicators of keloid under the action of different concentration of photosensitizer aminoketovaleric acid combined with laser.Methods Fifteen healthy nude mice were randomly divided into experimental group 1,experimental group 2 and control group.Keloid tissue was implanted into the back to form stable pathological scars.10％ aminoketovaleric acid solution,20％ aminoketovaleric acid solution,saline solution were applied to the back of the nude mice within 4,8 and 12 weeks,respectively,for half an hour,635 nm CW laser irradiation,and scar tissue was cut at 6,10 and 14 weeks for detection.Scar related indicators.Results Scar index,number of fibroblasts,number of TGF-beta 1 protein and alpha-SMA in the experimental group were lower than those in the control group,and more than 2 indexes in the experimental group were lower than those in the experimental group 1.There was significant difference among the groups.Conclusion 20％ aminoketovaleric acid can produce cytotoxic effect,induce apoptosis of fibroblasts,regulate and reduce epithelial-mesenchymal transition of scar,and inhibit keloid.