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目的:研究不同比例的人参藏红花组合物对急性高原反应的预防作用。方法:将小鼠按照体重随机分为7组:平原空白组、高原空白组、参花生药量比100∶1、50∶1、25∶1、10∶1、3∶1组。人参藏红花组合物总给药量10 g/kg。预先给予小鼠人参藏红花组合物8 d,末次给药1 h,经过低压环境及负重游泳后测定其血常规及乳酸(LD)、尿素氮(BUN)的值。结果:小鼠经过低压环境和负重力竭游泳后,参花组合物10 g/kg(参花生药量比25∶1)可使其血清乳酸增高,参花组合物10 g/kg(参花生药量比50∶1)具有较好的提高红细胞,血红蛋白,降低血小板的作用,而参花组合物各比例组对尿素氮均无明显影响。结论:人参藏红花组合物可能提高小鼠的无氧运动能力,可用于预防急性高原反应。
Objective: To study the prophylactic effect of different proportions of ginseng saffron composition on acute altitude sickness. Methods: The mice were randomly divided into 7 groups according to body weight: plain group, highland blank group, ginseng peanut dose ratio 100: 1,50: 1,25:1,10:1,3:1 group. Ginseng saffron composition total dose of 10 g / kg. The mouse ginseng safflower composition was pre-given for 8 days and the last administration for 1 hour. The blood routine, lactic acid (LD) and urea nitrogen (BUN) were measured after low pressure environment and weight-bearing swimming. Results: After low-pressure environment and exhaustive-load swimming, the ginseng composition 10 g / kg (ginseng ginseng dose ratio 25: 1) increased the serum lactate, ginseng composition 10 g / kg Dose ratio of 50: 1) has a better increase of red blood cells, hemoglobin, reduce platelet function, and the proportion of the composition of the flower oil group had no significant effect on urea nitrogen. Conclusion: The ginseng saffron composition may increase the anaerobic capacity of mice and may be used to prevent acute altitude sickness.