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心力衰竭的进展中伴随着心肌能量代谢的改变,能量代谢的异常又进一步促进心脏重构.左卡尼汀是一种通过促进心肌细胞内葡萄糖氧化来改善心肌能量代谢的制剂.现对近年来关于其对慢性心力衰竭患者的临床症状、运动能力、超声心动图参数和总体预后的影响以及对射血分数保留的心力衰竭的作用等方面的探索性研究进行了总结与思考.“,”In failing hearts,there is a change in the energy producing pattern of cardiomyocytes,which promotes cardiac remodeling.L-carnitine promotes glucose oxidation in cardiomyocytes,thus improving myocardial energy metabolism.In this article,we summarized studies about the effects of L-carnitine on clinical symptoms,exercise capacity,echocardiography parameters and prognosis in patients with heart failure.