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目的 :研究急性低氧和低氧习服对大鼠血浆内皮素、血管紧张素、心房利尿钠肽 (atrialnatriureticpeptideANP)和C型利尿钠肽 (C_typenatriureticpeptide ,CNP)含量的影响。方法 :间断低氧习服大鼠 (30 0 0m、5 0 0 0m各4h/d ,共 2周 )和正常大鼠经 80 0 0m缺氧 4h后 ,观察其血浆内皮素、血管紧张素、ANP和CNP含量的变化。结果 :低氧时大鼠血浆内皮素含量有增加的趋势 ,低氧对血浆CNP含量无明显影响。急性低氧时大鼠血浆ANP、血管紧张素Ⅰ (AngⅠ )和血管紧张素Ⅱ (AngⅡ )含量显著增高。低氧习服后 ,ANP和AngⅠ含量显著降低 ,接近正常水平 ,AngⅡ含量有下降趋势。结论 :大鼠经间断低氧习服后 ,血浆ANP和AngⅠ含量显著降低 ,可能是心脏低氧习服的机制之一。
Objective: To investigate the effects of acute hypoxia and hypoxia on plasma endothelin, angiotensin, atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) in rats. Methods: The rats were randomly divided into hypoxia (30 000, 40000 for 4h / d for 2 weeks) and normal rats for 4 hours hypoxia (80 000) for observation of plasma endothelin, angiotensin, ANP and CNP content changes. Results: The plasma endothelin level increased in hypoxia rats. Hypoxia had no significant effect on plasma CNP levels. In acute hypoxia, plasma ANP, Ang I and Ang II levels were significantly increased. After hypoxia, the levels of ANP and Ang I significantly decreased, approaching the normal level, and the content of Ang Ⅱ decreased. CONCLUSION: The plasma ANP and Ang I levels decreased significantly after intermittent hypoxia in rats, which may be one of the mechanisms of cardiac hypoxia acclimation.