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目的 观察慢性乙型肝炎（ＣＨＢ） 、肝硬化（ＬＣ） 患者血清转化生长因子β１（ＴＧＦβ１） 与肝细胞损伤、肝脏纤维组织增生的关系。方法 采用酶联免疫吸附试验（ＥＬＩＳＡ） 测定７６ 例ＣＨＢ、ＬＣ患者血清ＴＧＦβ１ 。肝活检２９ 例，应用多媒体彩色图文分析系统对肝内胶原纤维、网状纤维进行定量分析。结果 （１） ＣＨＢ轻、中、重度、ＬＣ 患者血清ＴＧＦβ１ 水平分别为（１４４ ．３ ±５７ ．１）ｍｇ／Ｌ、（３９４ ．５ ±１０７ ．７）ｍｇ／Ｌ、（５０８ ．３ ±１３３ ．３）ｍｇ／Ｌ、（５７９ ．４ ±２２５ ．１）ｍｇ／Ｌ，依次升高（ Ｐ＜ ０ ．０１ 或Ｐ＜ ０ ．０５） ；明显高于对照组（９５ ．３ ±３４ ．１）ｍｇ／Ｌ（ Ｐ＜ ０ ．０１） 。（２） 血清ＴＧＦβ１ 与Ⅲ型前胶原蛋白（ＰＣⅢ） 、层粘连蛋白（ＬＮ） 、透明质酸（ＨＡ） 呈正相关（ Ｐ＜ ０ ．０１ 或Ｐ＜ ０ ．０５） ；血清ＴＧＦβ１ 升高与肝组织纤维化程度的加重、肝组织内胶原纤维、网状纤维含量的增长呈同步性（ Ｐ＜ ０ ．０１ 或Ｐ＜ ０ ．０５） 。（３） ＡＬＴ＞ １６０Ｕ／Ｌ组、ＳＢ＞ ８５ ．５μｍｏｌ／Ｌ组血清ＴＧＦβ１ 水平明显高于肝功能轻度异常和正常组（ Ｐ?
Objective To observe the relationship between serum transforming growth factor-β1 (TGF-β1) and hepatocellular injury and hepatic fibrosis in patients with chronic hepatitis B (CHB) and cirrhosis (LC). Methods Serum TGF-β1 was detected in 76 CHB and LC patients by enzyme-linked immunosorbent assay (ELISA). Liver biopsy in 29 cases, the application of multimedia color image analysis system of liver collagen fibers, reticular fibers for quantitative analysis. Results (1) Serum levels of TGF-β1 were (144.3 ± 57.1) mg / L, (394.5 ± 107.7) mg / L, (P <0.01 or P <0.05), which was significantly higher than that of the control group (95.3 ± 34.3 ± 34.33 mg / L, 579.4 ± 225.1 mg / L, .1) mg / L (P <0 .01). Serum TGF-β1 was positively correlated with type Ⅲ procollagen (PCⅢ), laminin (LN), and hyaluronic acid (HA) (P <0.01 or P <0.05) Increased liver fibrosis with the degree of aggravating, hepatic collagen fibers, mesangial fibers increased in a synchronized (P <0.01 or P <0.05). (3) ALT> 160U / L group, SB> 85. The level of TGF-β1 in 5μmol / L group was significantly higher than that in mild dysfunction group and normal group (P =